How to install Nanodrop 1000 software (ND1000) on Windows 10

I occasionally use Nanodrop 1000 software (ND1000) in my lab's computer to check concentration and purity of nucleic acids. Sometimes I wanted to utilize Data viewer of the software in my personal computer where Windows 10 is installed. Unfortunately, Nanodrop 1000 software can be installed only on old versions of Windows OS, showing an error message below when I execute a setup file.

Maybe I can install Windows 7 and the software on virtual machine, but I need to endure inconvenience to turn on and off it every time I want to use the software. So, I looked for a way to figure out this issue and got it. I hope my post can help those who want to use Nanodrop 1000 on Windows 10.  

Requirements

1. Setup file of ND1000 software
2. uniextract

First, you need Setup file of ND1000 software. You can download it from a website of ThermoFisher site (link). Second, uniextract is a software to unpack files in setup file. I used this program to unpack and installed individual setup files included in ND1000 software. You can download uniextract here.  

Procedure

1. Install ND-1000 software

1. Unzip ND1000-3.8.1.zip and uniextract161_noinst.rar.
   
2. Run uniextract. 
3. Set path of ND1000 setup file and click OK.
4. Select "Not an InstallShield Installer" when Extract Method pop-up comes.
   
5. Go to the directory where ND1000 setup files are unpacked. (If you didn't change "Destination directory" in the step 3, the directory the files are unpacked would be the same directory of the ND1000 setup file is located.)
   
6. Go to the "ND1000" directory.
7. Run "lvruntimeeng71.exe" in the"LVRuntime7" directory.
8. Run "setup.exe" in the "NI-VISA 4.4.1" directory. (Restart is required after installation)
9. Run "NanoDrop 1000 V3.8.1.exe".

2. Install driver

1. Install driver on your PC. Folder names where installers are located are "32bitDriver" or "64bitdriver".
2. Edit registry. Windows 10 does not recognize Nanodrop machine right after USB connection. So you need to edit registry to make PC recognize the machine.
   1. Open regestry editor. Run run.exe (shortcut: [Win] + R), type regedit and click "OK".
   2. Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\usbflags.
   3. Add a key named vvvvpppprrrr. In windows 7 PC where ND-1000 is installed, open 'Device Manager'. Find ND-1000 from USB controllers, right-click and select properties. Go to tab [Details] and select 'Hardware ID'. You can find the encoded hardware ID like USB\SOME LETTERS\VIDvvvv\PIDpppp\REVrrrr. vvvv: 4 letters next to VID. pppp: 4 letters next to PID. rrrr: 4 letters next to REV. My nanodrop ID is 245710020002. You can try this ID first.
3. Add a DWORD (32-bit) value named "SkipBOSDescriptorQuery".
   1. On the 'Edit' menu, point to 'New', and then click 'DWORD (32-bit) Value'.
   2. Type SkipBOSDescriptorQuery for the name of the DWORD Value, and then press ENTER.
   3. Right-click SkipBOSDescriptorQuery, and then click Modify.
   4. In the Value data box, type 1 , and then click OK.
4. Exit Registry Editor.

Acknowledgement

Michel Villerius from Leiden University medical center gave me instruction to make Windows 10 recognize Nanodrop machine.  

Links

• Webpage of Nanodrop from ThermoFisher https://www.thermofisher.com/kr/ko/home/industrial/spectroscopy-elemental-isotope-analysis/molecular-spectroscopy/ultraviolet-visible-visible-spectrophotometry-uv-vis-vis/uv-vis-vis-instruments/nanodrop-microvolume-spectrophotometers/nanodrop-software-download.html
• Website of uniextract https://www.legroom.net/software/uniextract#download

 

Change logs

2019-11-11 Mon. Instruction for driver installation was added in this post.
2019-11-26 Tue. Post from wordpress has been moved to this site.